Welcome to the laboratory of Dr. Brad Day at Michigan State University. Research in the Day lab focuses on the molecular-genetic and biochemical processes associated with the interaction between plants and pathogens.
Specifically, we are interested in how plants protect themselves from pathogen infection using both preformed and induced defense responses. Using a combination of cell biology, biochemistry, and genetics, we are investigating how the actin cytoskeleton impacts defense signaling in the model system Arabidopsis thaliana. This work is currently supported by grants from the National Science Foundation and the National Institutes of Health.
We are also using genetics and biochemistry to ask how gene-for-gene resistance signaling is initiated during the early stages of the host-pathogen association, including how signaling is modulated in response to the environment. This project is an extension of a recent NSF Award, and is currently supported by the MSU Plant Resilience Institute.
Finally, a recently USDA project in the lab aims to develop highly specific DNA-based nanosensors for the detection of plant pathogens. This work involves a combination of genomics, cell biology, and chemistry to deploy a gold nanoparticle-based detection system developed by our lab, in collaboration with the laboratory of Dr. Evangeline Alocilja, to detect the presence of pathogens in plants.
More details about projects, people and future directions can be found throughout this webpage. If you are interested in joining the lab, please contact us to inquire about current postdoctoral and graduate student opportunities!